Drug-eluting intravascular prostheses and methods of use

Details Drug-eluting intravascular prostheses and methods of use Drug-eluting intravascular prostheses and methods of use

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61F 2/06 (2006.01) A61K 38/18 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2637662

The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth factor. The device can be coated with a biodegradable drug-eluting polymer that is impregnated with the inhibitor of smooth muscle cell proliferation and the growth factor. The device is useful for treating or preventing a vascular disease or disorder such as restenosis, by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention.

La présente invention concerne des prothèses intravasculaires et des méthodes de production et d'utilisation. L'invention concerne un appareil implantable pour traiter une maladie ou un trouble vasculaire comprenant une prothèse intravasculaire qui contient un inhibiteur de prolifération cellulaire de muscle lisse et un facteur de croissance. L'appareil peut être enduit d'un polymère d'élution de médicament biodégradable imprégné d'un inhibiteur de prolifération cellulaire de muscle lisse et d'un facteur de croissance. L'appareil permet de traiter ou de prévenir une maladie ou un trouble vasculaire tel qu'une resténose, en inhibant simultanément une obstruction vasculaire et en facilitant une récupération de la paroi vasculaire après une intervention intravasculaire.

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