C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/08 (2006.01) A61K 31/4184 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 9/12 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2684886
The invention is directed to compounds having the formula: (I) wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
L'invention concerne des composés ayant la formule: (I) où Ar, r, n, X, R2-3 et R5-7 sont tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. Ces composés ont une activité d'antagoniste de récepteurs AT1 et une activité d'inhibition de néprilysine. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés; des procédés d'utilisation de tels composés; et un procédé et des intermédiaires pour préparer de tels composés.
Allegretti Paul
Choi Seok-Ki
Fatheree Paul R.
Gendron Roland
Hudson Ryan
Theravance Inc.
Torys Llp
LandOfFree
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