C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/38 (2006.01) A61K 31/44 (2006.01) A61P 9/00 (2006.01) C07D 213/57 (2006.01) C07D 401/12 (2006.01) C07D 491/056 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2585165
Pyridoxine analogs , particularly bis-amidine pyridoxine analogs with antiplatelet and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular and cardiovascular related diseases and symptoms are described. The methods are directed to administering pharmaceutical compositions comprising substituted bis-amidine pyridoxine analogs having the following formulas:(I),(II),(III). wherein at least two of substituents R1- R6 have amidine groups.
La présente invention a pour objet des analogues de pyridoxine, plus particulièrement des analogues de pyridoxine de type bis-amidine, qui présentent des propriétés anti-plaquettes et anti-coagulantes. Lesdits analogues sont destinés au traitement de maladies ou de symptômes de maladies cardiovasculaires et apparentées, ainsi que de maladies ou de symptômes de maladies cérébro-vasculaires. Lesdites méthodes consistent en l~administration de préparations pharmaceutiques comprenant des analogues de bis-amidine pyridoxine substitués de formules suivantes : (I), (II), (III), où au moins deux des substituants R1-R6 portent des groupements amidine.
Diakur James
Haque Wasimul
Khan A. Qasim
Omar Mohammed
Pham Vinh
Medicure International Inc.
Ridout & Maybee Llp
LandOfFree
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