E - 5 - (2-halogenovinyl) - 2' - deoxycytidines

Details E - 5 - (2-halogenovinyl) - 2' - deoxycytidines E - 5 - (2-halogenovinyl) - 2' - deoxycytidines

C - Chemistry, Metallurgy

07

H

260/229.4

C07H 19/06 (2006.01)

Patent

CA 1173438

A B S T R A C T E-5-(2-haloqenovinyl)-2'-deoxycytidines The invention relates to E-5-(2-halogenovinyl)-2'- deoxycytidines, e.g. E-5-(bromovinyl)-2'-deoxycytidine and E-5-(2-iodovinyl)-2'-deoxycytidine. These substances are endowed with specific antiviral activities towards herpes simplex virus and with an extremely low toxicity which makes them useful in antiviral medicines and for treatment of virus diseases in man and animal. They may be synthesised by introduction of an E-5-(2-halogenovinyl) sidechain into 2'-deoxycytidine, or by condensation of a trialkylsilyl derivative of E-5-(2-halogeno- vinyl)-cytosine with a hydroxyl-protected reactive derivative of 2'-deoxy-D-erythro-pentofuranose.

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