G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) A61K 38/46 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2377228
Disclosed is the ability of the adenovirus protein, E4orf4, to induce cell death in neoplastic cells, but not in non-neoplastic cells. This discovery allows for the generation of anti-neoplastic therapeutic reagents and compounds. In addition, the invention provides methods for screening for E4orf4 analogs having anti-neoplastic properties.
Cette invention concerne l'aptitude de la protéine adénovirale E4orf4 à provoquer la mort de cellules néoplasiques, mais pas de cellules non néoplasiques. Cette découverte ouvre la voie à la mise au point de réactifs et de composés thérapeutiques anti-néoplasiques. De plus, l'invention concerne des méthodes de criblages d'analogues E4orf4 présentant des propriétés anti-néoplasiques.
Branton Philip E.
Bussey A. Howard
Lee Joseph M.
Marcellus Richard C.
Roopchand Diana E.
Smart & Biggar
University Mcgill
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