Eating suppressant peptides

Details Eating suppressant peptides Eating suppressant peptides

C - Chemistry, Metallurgy

07

K

C07K 14/775 (2006.01) A23L 1/305 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2185450

Peptides corresponding to specific portions of apolipoprotein A-IV (apo A-IV) are provided. Most of the peptides correspond to the amino terminal region of apo A-IV. In addition, those peptides corresponding to the amino terminal portion of apo A-IV substantially correspond to a fundamental repeat unit of twenty two amino acids comprising: D Y F T Q L S N N A K E A V E Q L Q K T D V as well as homologs and analogs thereof. The peptides have eating suppressant properties when administered centrally or peripherally, the peptides may be used in compositions and methods for suppressing the appetite and controlling food intake.

Peptides correspondant à des portions spécifiques de l'apolipoprotéine A-IV (apo A-IV) dont la plupart correspondent à la région aminoterminale de l'apo A-IV et qui correspondent en outre sensiblement à l'unité fondamentale de répétition de vingt deux acides aminés D Y F T Q L S N N A K E A V E Q L Q K T D V, et leurs homologues et analogues. Lesdits peptides, qui sont des coupe-faim administrables par voie centrale ou périphérique, peuvent être associés à des compositions et méthodes de suppression de l'appétit et de régulation de l'ingestion des aliments.

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