Echinocandin derivatives, preparation method and application...

Details Echinocandin derivatives, preparation method and application... Echinocandin derivatives, preparation method and application...

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) A61K 38/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311295

The invention concerns compounds of formula (I) in which: either R1 and R2 = H, OH, alkyl optionally substituted, or NR1 forms with the carbon bearing NR1R2 a double bond and R2 is Xra, X being O, NH or N-alkyl and Ra being H, alkyl optionally substituted; R = a chain containing up to 10 carbon atoms, optionally comprising one or several heteroatoms, one or several heterocycles; T = H, CH¿2?, CH¿2?CONH¿2?, CH¿2?C?N, (CH¿2?)2NH¿2?; Y = H, OH, halogen; W = H, OH; Z = H OR CH¿3?. Said products have antifungal properties.

L'invention a pour objet les composés de formule (I), ou bien R1 et R2 = H, OH, alkyle éventuellement substitué, ou bien NR1 forme avec le carbone portant NR1R2 une double liaison et R2 est Xra, X étant O, NH OU N-alkyle et Ra étant H, alkyle éventuellement substitué, R = chaîne renfermant jusqu'à 30 atomes de carbone, renfermant éventuellement un ou plusieurs hétéroatomes, un ou plusieurs hétérocycles, T = H, CH3, CH2CONH2, CH2CN, (CH2)2NH2, Y = H, OH, Halogène, W = H, OH, Z = H ou CH3. Les produits présentent des propriétés antifongiques.

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