C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103.1, 167/1
C07K 14/525 (2006.01) A61K 38/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1265444
Abstract A method for the production and purification of human tumor necrosis factor (hTNF) is described. This purified material, shows growth inhibitory, hemorrhagic necrosis, cytotoxicity, and cytostasis effects on a variety of human tumors and cancers. The hTNF is free of exogeneous endotoxin, bacteria, and serum factors. hTNF has a molecular weight of about 70,000 hTNF and human interferon used together have a far greater growth inhibitory or cytotoxic effect on human tumors than the sum of their separate effects. The effect is synergistic and is seen with alpha-, beta- or gamma-IFN and with natural and recombinant IFN.
455737
Carswell Richards Elizabeth A.
Old Lloyd J.
Prendergast Jay S.
Rubin Berish Y.
Williamson Barbara D.
Carswell Richards Elizabeth A.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Old Lloyd J.
Prendergast Jay S.
Rubin Berish Y.
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