Egf receptor epitope peptides and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/71 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2556632

The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.

La présente invention se rapporte en général à des peptides d'épitopes de récepteurs de facteurs de croissance, et notamment à des peptides d'épitopes de récepteurs de la familles des EGF. La présente invention se rapporte également à l'utilisation des peptides de récepteurs dans la production d'anticorps présentant une activité antitumorale ou anticancéreuse ou dans la stimulation d'une réponse immunitaire. Par ailleurs, la présente invention se rapporte à des anticorps dirigés spécifiquement contre les peptides de récepteurs. On a également prévu des procédés de production d'une réponse immunitaire et de traitement de tumeurs et de cancers.

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