A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61K 41/00 (2006.01) A61K 45/00 (2006.01) A61N 1/00 (2006.01) A61N 1/30 (2006.01) A61N 1/32 (2006.01) C12M 1/42 (2006.01)
Patent
CA 2361601
Electrically-mediated delivery technology has been applied to DNA vaccines and substantially higher immune responses have been achieved. In mice and rabbits vaccinated with DNA encoding HIV genes, when administered with constant electric current or constant electric voltage, up to twenty-fold higher immune responses were achieved compared with application of DNA vaccines alone. The increase was achieved under conditions of both constant current (iontophoresis) and constant voltage (electroporation).
L'invention concerne une technique d'injection électriquement induite appliquée à des vaccins d'ADN, qui a permis d'obtenir des réponses immunitaires sensiblement plus importantes. On observe chez les souris et les lapins vaccinés avec de l'ADN codant pour des gènes VIH, des réponses immunitaires jusqu'à vingt fois plus importantes qu'avec des vaccins d'ADN uniquement, lorsqu'ils sont administrés en association avec un courant électrique constant ou une tension électrique constante. L'augmentation a été obtenue dans des conditions de courant constant (ionophorèse) et de tension constante (électroporation).
Goldbeck Cheryl
Liu Margaret A.
Pertile Terry
Selby Mark
Ulmer Jeffery
Borden Ladner Gervais Llp
Chiron Corporation
Emed Corporation
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