Electrochemical detection of ischemia

G - Physics – 01 – N

Patent

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G01N 27/327 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) G01N 27/49 (2006.01)

Patent

CA 2468236

The subject invention comprises electrochemical methods and device for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes (2, 4, 6) are used to measure the current or potential difference of non- sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.

L'invention concerne des procédés électrochimiques et des dispositifs de détection in vitro d'un événement ischémique dans un échantillon prélevé chez un patient. Après l'ajout d'une quantité connue d'un ion d'un métal de transition dans ledit échantillon, des électrodes (2, 4, 6) sont utilisées pour mesurer le courant ou la différence de potentiel d'ion d'un métal de transition non séquestré dans l'échantillon. La quantité d'ion d'un métal de transition non séquestré dans l'échantillon reflète le degré de modification apporté à l'albumine correspondant à un événement ischémique.

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