A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/5383 (2006.01) A61K 31/58 (2006.01) A61K 38/19 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2618721
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
L'invention concerne des procédés visant à supprimer ou à inhiber des tumeurs comprenant des populations de cellules hétérogènes ou mixtes. Pour ce faire, on cible sélectivement un ligand unique suspecté d'être exprimé sur une population de cellules particulières, de manière à supprimer également la population de cellules dépourvues du ligand unique. Ces conjugués ont une utilité thérapeutique lorsqu'ils sont administrés à une population de cellules spécifiques afin de supprimer celles-ci, le médicament cytotoxique étant libéré pour supprimer les cellules non ciblées afin d'éliminer la tumeur.
Chari Ravi V. J.
Erickson Hans K.
Goldmakher Viktor S.
Kovtun Yelena V.
Lambert John M.
Gowling Lafleur Henderson Llp
Immunogen Inc.
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