Enantiomeric dynemicin analogs, preparation and use thereof

Details Enantiomeric dynemicin analogs, preparation and use thereof Enantiomeric dynemicin analogs, preparation and use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 31/47 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 491/02 (2006.01) C07D 491/04 (2006.01) C07D 491/08 (2006.01) C07D 491/10 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01) C07H 11/00 (2006.01) C07H 15/26 (2006.01) C07H 17/02 (2006.01)

Patent

CA 2136234

2136234 9323046 PCTABS00028 An enantiomer of a fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The enantiomeric compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties that are enhanced over their racemates. Chimeric compounds having the enantiomeric fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing an enatiomeric compound or an enantiomeric chimer are disclosed, as are methods of preparing an enantiomeric compound.

Affiliated with

Also associated with

Rating

Enantiomeric dynemicin analogs, preparation and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enantiomeric dynemicin analogs, preparation and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enantiomeric dynemicin analogs, preparation and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1766787