C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/08 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2655789
The present invention relates to an enantiomerically pure (+)-trans-enantiomer of a compound represented by the following formula (I): wherein R1, R2, R3, R4 and R9 are as defined in the specification; enantiomerically pure intermediates thereof, to processes for the preparation of the enantiomerically pure compound and its intermediates, and to a pharmaceutical composition comprising the enantiomerically pure compound. The compound of formula (I) is useful for the treatment of diseases or disorders mediated by the inhibition of cyclin dependant kinase, such as cancer.
La présente invention concerne un énantiomère (+)- trans énantiomériquement pur représenté par la formule suivante (I): R1, R2, R3, R4 et R9 étant tels que définis dans la description; l'invention concerne aussi des intermédiaires énantiomériquement purs de celui-ci, des procédés de préparation du composé énantiomériquement pur et de ses intermédiaires, ainsi qu'une composition pharmaceutique comprenant le composé énantiomériquement pur. Le composé de formule (I) est utile pour le traitement de maladies ou de troubles associés à l'inhibition de la kinase cycline-dépendante, tel le cancer.
Jadhav Pramod Kumar
Joshi Kalpana
Mascarenhas Malcolm
Rathos Maggie
Sarde Ankush
Piramal Life Sciences Limited
Riches Mckenzie & Herbert Llp
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