Encapsulation of antineoplastic agents in liposomes

Details Encapsulation of antineoplastic agents in liposomes Encapsulation of antineoplastic agents in liposomes

A - Human Necessities

61

K

167/163, 117/46.

A61K 9/60 (2006.01) A61K 9/127 (2006.01) A61K 9/52 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1270198

ABSTRACT OF THE DISCLOSURE Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.

488005

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