Endothelial cell specific antibodies and uses thereof

Details Endothelial cell specific antibodies and uses thereof Endothelial cell specific antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2518490

Methods and composition provided herein relate to the inhibition of proliferation, migration, and tubule formation of endothelial cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis. Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.

La présente invention se rapporte à des procédés et à des compositions qui sont destinés à inhiber la prolifération des cellules endothéliales, leur migration et la formation de tubules de ces dernières, et qui sont donc utiles pour traiter les maladies associées à l'angiogenèse, notamment le cancer, la polykystose rénale, la rétinopathie diabétique, l'arthrite rhumatoïde et le psoriasis. L'invention a également trait à des procédés permettant d'inhiber la prolifération de cellules endothéliales, leur migration et la formation de tubules de ces dernières, par l'administration d'un anticorps spécifique des marqueurs endothéliaux tumoraux (TEM). L'invention concerne aussi des procédés permettant d'inhiber l'angiogenèse et la croissance tumorale, par l'administration d'un anticorps spécifique des TEM, et des compositions d'anticorps utiles dans de tels procédés.

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