Endothelin antagonistic substance

Details Endothelin antagonistic substance Endothelin antagonistic substance

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 31/435 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 401/12 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2084163

Disclosed is a peptide derivative of the formula: (see formula I) (wherein: A is R11O-CO- (wherein R11 is alkyl or phenyl) , or R12R13N-C(=O)- (wherein R12 is alkyl, cycloalkyl, 1-adamantyl, optionally substituted phenyl, pyridyl or thienyl and R13 is H, alkyl or cycloalkyl or R12 and R13 form, together with the adjacent nitrogen atom, a 5- to 9-membered nitrogen-containing saturated heterocyclic ring having 4 to 8 carbon atoms, optionally methylene replaced by thio and optionally having substituent or being benzo-fused); B is O or -NR2- (wherein R2 is H or alkyl); R3 is alkyl, cycloalkyl, aryl, heterocyclic, cycloalkyl-alkyl, aryl-alkyl or heterocyclic-alkyl; X1 is O or -NR4- (wherein R4 is H or alkyl); R5 is a 3-indolylmethyl, 3-benzothienylmethyl, 1- naphthylmethyl or benzyl group, each optionally substituted; X3 is O or S; R6 is H, alkyl or alkenyl; n is 0 or 1; Y is CH2OH, CO2R71 (wherein R71 is H or alkyl) , CONHR72 (wherein R72 is H or alkyl), 1H-tetrazol-5-yl, sulfo or phosphono) or a pharmaceutically acceptable salt thereof, which has endothelin antagonistic activity and is useful as a drug.

Affiliated with

Also associated with

Rating

Endothelin antagonistic substance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endothelin antagonistic substance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin antagonistic substance will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1423372