Endothelin receptor antagonists

Details Endothelin receptor antagonists Endothelin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 285/14 (2006.01) A61K 31/41 (2006.01) C07D 271/12 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2297315

The invention relates to novel compounds of formula (I), wherein R represents group (1), X stands for O or S, and R1, R2, R3, R4, R5 and R6 have the meaning cited in Claim 1, or a tauomeric cyclized form. The invention further relates to (E) isomers and their salts. Said novel derivatives exhibit endothelin- receptor antagonistic properties.

Des nouveaux composés correspondant à la formule (I), dans laquelle R représente le groupe (1), X représente O ou S et R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ correspondent à la définition donnée dans la revendication 1, ou bien une forme tautomère fermée en cycle, ainsi que les isomère (E) et les sels de ces nouveaux composés ont des propriétés antagonistes vis-à-vis des récepteurs de l'endothéline.

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