Enhancing treatment of hif-1 mediated disorders with...

Details Enhancing treatment of hif-1 mediated disorders with... Enhancing treatment of hif-1 mediated disorders with...

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A01N 1/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2585581

The present invention relates to the use of adenosine receptor agonists, preferably A3 receptor agonists, either alone or in combination with other agents for the treatment, prevention and/or management of diseases or disorders associated with under~expression of HIF-1 .alpha. and/or decreased HIF-1 .alpha.activity (e.g., ischemic related disorders). The methods of the invention are directed to methods of reducing tissue damage (e.g., substantially preventing tissue damage, inducing tissue protection) resulting from ischemia orhypoxia. The invention provides methods for treating, preventing and/or ameliorating one or more symptoms of hypoxic or HIF-la related disorders by administering an A3 receptor agonist either alone or in combination with other agents.

L'invention concerne l'utilisation d'agonistes du récepteur de l'adénosine, de préférence des agonistes du récepteur A3, soit seuls ou combinés à d'autres agents pour le traitement, pour la prévention et/ou pour la gestion de maladies ou de troubles associés à la sous-expression de HIF-1 a et/ou à l'activité diminuée de HIF-1 a (par exemple troubles associés ischémiques). Les méthodes de l'invention concernent des méthodes de réduction de lésions tissulaires (par exemple des méthodes de prévention sensibles de lésions tissulaires induisant une protection tissulaire) résultant d'une ischémie ou d'une hypoxie. L'invention concerne également des méthodes pour traiter, prévenir et/ou soulager au moins un symptôme de troubles hypoxiques associés au HIF-1 .alpha., en administrant un agoniste du récepteur A3, soit seul ou combiné à d'autres agents.

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