Enzymatic process for the conversion of preproinsulins into...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/02 (2006.01) C07K 14/62 (2006.01) C12N 9/48 (2006.01)

Patent

CA 2050606

An enzymatic process for the conversion of preproinsulins into insulins A process for the specific hydrolysis of the amino-acid chain of preproinsulins to give the corresponding inter- mediates using clostripain is described, and these intermediates can, where appropriate, be converted with carboxypeptidase B into the corresponding insulins.

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