C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) C07K 1/107 (2006.01) C07K 14/585 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/88 (2006.01)
Patent
CA 2043565
4-18 11 0/A/CGJ44 ABSTRACT Novel Enzyme and DNA coding therefor The invention concerns a peptidylhydroxyglycine N-C lyase (PHL) catalyzing the reaction R-GlyOH ? R-NH2 wherein R represents a peptide residue, and GlyOH represents an .alpha.-hydroxyglycine residue linked to the C-terminus of said peptide R by an amide bond, a recombinant DNA molecule coding for a PHL a method for the preparation of such a recombinant DNAmolecule, processes for the preparation of PHL from a natural source or by means of the said recombinant DNA molecule, and the use of PHL for the preparation of an amidated peptide R-NH2.
Ghisalba Oreste
Iwasaki Yasuno
Kangawa Kenji
Kawahara Takashi
Nishikawa Yoshiki
Fetherstonhaugh & Co.
Novartis Ag
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