Enzyme inhibition immunoassay based on impdh inhibition by mpa

Details Enzyme inhibition immunoassay based on impdh inhibition by mpa Enzyme inhibition immunoassay based on impdh inhibition by mpa

C - Chemistry, Metallurgy

07

H

C07H 15/26 (2006.01) C07D 307/88 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 473/08 (2006.01) C07H 13/02 (2006.01) C07H 13/08 (2006.01) C07J 19/00 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C12Q 1/32 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2455097

A method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand to form a ligand-inhibitor conjugate which is utilized in a homogeneous assay. The ligand-inhibitor conjugate has a structure: (see above formula) wherein: n = 1-2, and X is a drug derivative selected from the group of: phenytoin-3-butyramido-, gentamicin(C1a)-N1-carbonyloxy-, gentamicin(C1a)-N1-teraphthaloylamino-, 5'-[[[(digoxin(1,4-oxazepin))-4-yl]-phenyl-4-carbonyl]amino]-, and 5'-[[[(digitoxin(1,4-oxazepin))-4-yl]-phenyl-4-carbonyl]amino]-. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides the novel ligand-inhibitor conjugates, assay reagents and packaged kits useful for performing such measurements.

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