Epitope-beta microglobulin polynucleotide for anti-cancer...

A - Human Necessities – 61 – K

Patent

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A61K 38/16 (2006.01) A61K 35/56 (2006.01) A61K 39/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07K 14/11 (2006.01) C07K 14/74 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2463623

The present invention relates to polynucleotides for use in cancer therapy. In particular, the invention provides a polynucleotide capable of expressing an epitope-.beta.2m fusion protein; for use in the generation of cytotoxic T lymphocyte (CTL) responses against a tumour; and a polynucleotide capable of expressing an epitope-.beta.2m fusion protein; for use in a method of restoring antigen presentation in the tumour of a host.

La présente invention concerne des polynucléotides destinés à une utilisation dans la thérapie du cancer. La présente invention concerne en particulier un polynucléotide pouvant exprimer une protéine de fusion .beta.¿2?m épitope destinée à produire des réponses de lymphocytes T cytotoxiques contre une tumeur, ainsi qu'un polynucléotide pouvant exprimer une protéine de fusion .beta.¿2?m épitope destinée à un procédé de reconstitution de la présentation d'antigène dans la tumeur d'un hôte.

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