C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/90 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2595848
The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3) . The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives, such like the compounds (1).
L'invention concerne des méthodes permettant de cribler des partenaires de liaison, en particulier, des partenaires de liaison essentiels pour l'activité biologique de l'érastine (par exemple, des VDAC tels que VDAC3). L'invention concerne également des réactifs et des méthodes permettant de tuer efficacement les cellules cancéreuses à l'aide de l'érastine ainsi que des composés et des dérivés correspondant.
Becklin Robert R.
Chepanoske Cindy Lou
Pelter John M.
Qi Longwu
Robbins Paul B.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Prolexys Pharmaceuticals Inc.
The Trustees Of Columbia University In The City Of New York
Whitehead Institute For Biomedical Research
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