Ergoline derivatives

Details Ergoline derivatives Ergoline derivatives

C - Chemistry, Metallurgy

07

D

260/206, 167/211

C07D 457/00 (2006.01) A61K 31/48 (2006.01) C07D 457/02 (2006.01) C07D 457/12 (2006.01)

Patent

CA 1293247

ABSTRACT OF THE DISCLOSURE An ergoline derivative of the formula I: Image I wherein R1 represents hydrogen or a methyl group; R2 represents hydrogen or a halogen atom, a methyl, cyano or phenyl group or an alkylthio group having from 1 to about 4 carbon atoms; R3 represents a hydrocarbon group having from 1 to about 4 carbon atoms; R4 represents hydrogen, a phenyl group or a hydrocarbon group having from 1 to about 4 carbon atoms; wherein either (a) R6 and R7 represent a valence bond or hydrogen atoms and R8 represents a hydrogen atom or a methoxy group, or (b) R6 represents a hydrogen atom and R7 and R8 taken together represent a valence bond; W represents an oxygen atom or an imino group; A represents a group of 25521-141 the formula CHR5, CH=CR5 or CH2CHR5 wherein R5 represents a hydrogen atom or an alkyl group having from 1 to about 4 carbon atoms; X represents an oxygen or sulphur atom or an imino group; and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof. These compounds are useful as antihypertensive agents.

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