Ethenyl-substituted pyridine and pyrimidine derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2734489

The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.

La présente invention porte sur des composés représentés par la formule (A) : (la formule chimique devrait être introduite ici telle qu'elle apparaît sur l'abrégé sous forme papier) (A) et les tautomères, isomères et esters desdits composés, et sur des sels, solvates et promédicaments pharmaceutiquement acceptables desdits composés, formule dans laquelle chacun parmi R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23 et n est choisi indépendamment et est tel que défini ici. L'invention porte également sur des compositions comprenant de tels composés. Les composés de l'invention sont efficaces en tant qu'inhibiteurs du VHC, et sont utiles, seuls ou conjointement avec d'autres agents thérapeutiques, dans le traitement ou la prévention de maladies ou de troubles tels que des infections virales et des troubles liés à un virus.

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