Ether compounds, compositions, and uses thereof

Details Ether compounds, compositions, and uses thereof Ether compounds, compositions, and uses thereof

C - Chemistry, Metallurgy

07

F

C07F 9/09 (2006.01) A61K 31/08 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/4166 (2006.01) A61K 31/661 (2006.01) C07C 43/13 (2006.01) C07C 59/125 (2006.01) C07C 311/24 (2006.01) C07D 233/72 (2006.01)

Patent

CA 2369074

The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

L'invention concerne de nouveaux composés d'éther et compositions renfermant de tels composés, ainsi que des procédés permettant de traiter et de prévenir des troubles cardiovasculaires, des dyslipidémies, la dyslipoprotéinémies et des troubles du métabolisme du glucose. Ces procédés consistent à administrer une composition renfermant un composé d'éther. Lesdits composés, compositions et procédés sont utiles dans le traitement de la maladie d'Alzheimer, du Syndrome X, de troubles relatifs aux récepteurs activés par le proliférateur de péroxisome, la septicémie, d'affections thrombotiques, de l'obésité, de la pancréatite, de l'hypertension, d'affections rénales, du cancer, d'inflammation et d'impotence. Dans certains modes de réalisation, les composés, compositions et procédés servent dans une polythérapie avec d'autres thérapeutiques, par exemple des agents hypocholestérolémiants et hypoglycémiques.

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