Etoposide analogues

Details Etoposide analogues Etoposide analogues

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/365 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2044211

ABSTRACT OF THE DISCLOSURE Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: Image where: R1 is .beta.-OCH2CH2NH2 .beta.-NHCH(CH3)CH2OH, .beta.- NHCH2CH(CH3)OH, .beta.-Cl, .beta.-Br, .beta.-OH, .alpha.-OH, .beta.-NH2, .alpha.- NH2, .beta.-NHCH2CH2OH, .alpha.-NHCH2CH2OH, .beta.-NHCH2CH2CH3, .beta.- NHCH2CH2OCH3, .beta.-NHCH2CH=CH2, .beta.-NHCH2CH(OH)CH3, .beta.- NHCH2CH2CH2OH, .beta.-OCH2CH2OH, Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image , Image or Image . R2 is H, or Br; R3 is H, or Br; R4 is H, or Br; R5 is H, or Br; and R6 is H, or -CH3.

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