Expression of xenogenous (human) immunoglobulins in cloned,...

Details Expression of xenogenous (human) immunoglobulins in cloned,... Expression of xenogenous (human) immunoglobulins in cloned,...

C - Chemistry, Metallurgy

07

K

C07K 16/06 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C07K 16/04 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2428053

The present invention relates to the production of a trangenic bovine which comprises a genetic modification that resulrs in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results on the expression of non-bovine antibodies, preferably human antibodies.

La présente invention se rapporte à la production d'un bovin transgénique comprenant une modification génétique qui engendre l'inactivation et la perte de l'expression de ses anticorps endogènes, ainsi que l'expression d'anticorps xénogènes, de préférence d'anticorps humains. Ceci est effectué par l'inactivation de l'expression à chaîne lourde d'IgM, et éventuellement, au moyen de l'inactivation de l'expression à chaîne légère d'Ig, puis par l'introduction d'un chromosome artificiel causant l'expression d'anticorps non bovins, de préférence d'anticorps humains.

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