C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/44 (2006.01) C07K 14/505 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2440221
Disclosed are methods and compositions for efficiently expressing antibody fusion proteins. Antibody fusion proteins of the invention include a hybrid antibody moiety containing sequences from more than one type of antibody and/or mutant antibody sequences. Hybrid antibody fusion proteins of the invention may be produced at high levels and may combine functional properties characteristic of different antibody types in addition to functional properties of a non-antibody moiety.
L'invention concerne des procédés et des compositions permettant d'exprimer efficacement des protéines hybrides d'anticorps. Les protéines hybrides d'anticorps de cette invention comprennent un fragment d'anticorps chimérique contenant des séquences de plus d'un type de séquences d'anticorps et/ou d'anticorps mutants. Les protéines hybrides d'anticorps chimérique de cette invention peuvent être produites à des niveaux élevés et peuvent combiner des propriétés fonctionnelles caractéristiques de différents types d'anticorps à des propriétés fonctionnelles d'un fragment qui n'est pas d'un anticorps.
Gillies Stephen D.
Lo Kin-Ming
Way Jeffrey
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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