Extracellular matrix receptor ligands that modulate...

Details Extracellular matrix receptor ligands that modulate... Extracellular matrix receptor ligands that modulate...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109398

ABSTRACT OF THE INVENTION Soluble fusion molecule containing the extracellular binding region of leukocyte receptors are described which are capable of binding to extracellular matrix associated proteins. The described lymphocyte to ligand proteins include soluble fusion molecules of 4-lBB, CD27, CD30, FAS, TNF receptor and CD40. A method of modulating leukocyte function is described in which a soluble lymphocyte between leukocyte receptors and the extracellular matrix associated protein of the target tissue.

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