Extracorporeal endotoxin removal method

Details Extracorporeal endotoxin removal method Extracorporeal endotoxin removal method

C - Chemistry, Metallurgy

07

K

C07K 1/22 (2006.01) A61L 2/00 (2006.01) A61L 2/02 (2006.01) B01D 61/00 (2006.01) B01D 67/00 (2006.01) B01D 69/14 (2006.01) B01J 20/32 (2006.01) C07K 1/34 (2006.01) C08G 69/10 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2383955

This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin adsorption ligands of the invention are oligopeptides synthesized from amino acids having a pk > 7.2 such as arginine, lysine or histidine, using a polycondensation step such that the resultant oligopeptides exhibit a high degree of polydispersity. Also provided are methods and devices using an adsorbent having a polydisperse oligopeptide of the invention immobilized on a solid state support medium for removing endotoxin from the blood of human or animal subject.

L'invention concerne un équipement de traitement du sang, capable d'éliminer du sang ou du plasma, de manière sélective, les substances formant les endotoxines et la cytokine, par adsorption extracorporelle, à des fins de traitement thérapeutique des chocs septiques. Les ligands adsorbant les endotoxines sont des oligopeptides synthétisés à partir d'acides aminés ayant un pK > 7,2, tels que l'arginine, la lysine ou l'histidine, au moyen d'une étape de polycondensation de façon que les oligopeptides obtenus présentent un degré élevé de polydispersité. L'invention concerne également des procédés et des dispositifs reposant sur l'utilisation d'un adsorbant renfermant l'oligopeptide polydispersé de l'invention, immobilisé sur un support à l'état solide afin d'éliminer les endotoxines du sang d'un sujet humain ou animal.

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