F11 receptor(f11r) antagonists as therapeutic agents

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A01N 37/18 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2512399

The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R- antagonists and methods for the prevention and treatment of thrombosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.

La présente invention concerne une molécule d'adhésion cellulaire (CAM), désignée en tant que récepteur de F11 (F11R), qui fait partie de la superfamille de l'immunoglobuline localisée à la surface des plaquettes humaines, et a pour rôle de promouvoir l'agrégation des plaquettes, la sécrétion, l'étalement des plaquettes et l'adhésion cellulaire. L'invention a également pour objet de l'ADNc de F11R cloné, de l'ADNc de F11R pleine longueur et des séquences d'acides aminés, ainsi que des antagonistes de F11R et des procédés pour prévenir et traiter la thrombose, l'infarctus du myocarde, l'accident vasculaire cérébral et autres troubles cliniques liés à la formation de thrombus.

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