Factor viii muteins with reduced immunogenicity

Details Factor viii muteins with reduced immunogenicity Factor viii muteins with reduced immunogenicity

C - Chemistry, Metallurgy

07

K

C07K 14/755 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2728708

The invention relates to modified Factor VIII molecules with reduced N-linked glycosylation and reduced immunogenicity. The invention also relates to methods of using modified Factor VIII molecules, for example, to treat patients afflicted with hemophilia.

Linvention concerne des molécules modifiées de facteur VIII qui présentent une glycosylation à liaison N réduite et une immunogénicité réduite. Linvention porte en outre sur des procédés dutilisation de molécules modifiées de facteur VIII, par exemple pour traiter des patients atteints dhémophilie.

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