Factor xa inhibitors

Details Factor xa inhibitors Factor xa inhibitors

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/4192 (2006.01) A61K 31/421 (2006.01) A61P 9/00 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2674843

The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

L'invention concerne des composés représentés par la formule (I) ou un sel, un ester ou un promédicament pharmaceutiquement acceptable de ceux-ci qui sont des inhibiteurs du facteur XA. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, des compositions pharmaceutiques contenant de tels composés, des procédés pour empêcher ou traiter un certain nombre d'affections caractérisées par une thrombose non souhaitée et des procédés d'inhibition de la coagulation d'un échantillon de sang.

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