C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2371193
A family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
L'invention décrit une nouvelle famille de molécules d'immunorécepteurs appartenant à la superfamille des immunoglobulines, les polypeptides LIR. Elle concerne des séquences codant les membres de la famille LIR et des séquences d'acides aminés déduites à partir de ceux-ci, des polypeptides codant l'ADN qui s'hybride avec des séquences nucléotidiques définies, des procédés permettant de produire des polypeptides de la famille LIR et des anticorps spécifiques dirigés contre les polypeptides LIR. On peut utiliser les membres de la famille LIR pour traiter des maladies auto-immunes et des états pathologiques associés à la fonction immunitaire supprimée.
Anderson Dirk M.
Borges Luis
Cosman David J.
Immunex Corporation
Smart & Biggar
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