Fap-activated anti-tumor compounds

Details Fap-activated anti-tumor compounds Fap-activated anti-tumor compounds

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01) A61K 38/04 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 15/252 (2006.01) C07K 1/06 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/11 (2006.01) C07K 5/117 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2369933

The invention relates to a prodrug that is capable of being converted into a drug by the catalytic action of human fibroblast activation protein (FAP.alpha.), said prodrug having a cleavage site which is recognised by FAP.alpha., and said drug being cytotoxic or cytostatic under physiological conditions.

L'invention concerne un promédicament pouvant être converti en médicament par action catalytique de la protéine d'activation fibroblastique humaine (FAP.alpha.). Ledit promédicament comprend un site de restriction reconnu par la protéine FAP.alpha., et devient cytotoxique ou cytostatique dans des conditions physiologiques.

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