Fap alpha-specific antibody with improved producibility

Details Fap alpha-specific antibody with improved producibility Fap alpha-specific antibody with improved producibility

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/40 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2327586

Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAP.alpha.) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes and methods of producing said antibodies.

L'invention concerne des anticorps protéiques recombinants liant spécifiquement des alpha protéines d'activation des fibroblastes (FAP.alpha.) et comprenant des modifications de structure permettant d'obtenir une production améliorée dans des cellules hôtes. L'invention concerne également l'utilisation desdits anticorps pour le diagnostic et pour des traitements, ainsi que des procédés de production desdits anticorps.

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