C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 38/37 (2006.01) A61K 38/48 (2006.01)
Patent
CA 2591914
Disclosed are new phosphatidylserine binding constructs with surprising combinations of properties, and a range of diagnostic and therapeutic conjugates thereof. The new constructs effectively bind phosphatidylserine targets in disease and enhance their destruction, and can also specifically deliver attached imaging or therapeutic agents to the disease site. Also disclosed are methods of using the new construct compositions, therapeutic conjugates and combinations thereof in tumor vasculature targeting, cancer diagnosis and treatment, and for treating viral infections and other diseases.
L'invention concerne, d'une part, de nouvelles constructions fixant la phosphatidylsérine, possédant d'étonnantes combinaisons de propriétés, et, d'autre part, des conjugués diagnostiques et thérapeutiques obtenus à partir de ces nouvelles constructions. Ces nouvelles constructions fixent efficacement des cibles de phosphatidylsérine dans des maladies et favorisent leur destruction et peuvent également libérer de manière spécifique des agents thérapeutiques ou des agents d'imagerie au niveau du site touché par la maladie. L'invention concerne également des méthodes destinées à l'utilisation de compositions contenant ces nouvelles constructions, des conjugués thérapeutiques et des combinaisons de ceux-ci dans le ciblage des vaisseaux tumoraux, dans le diagnostic et le traitement du cancer et dans le traitement d'infections virales ou d'autres maladies.
King Steven W.
Luster Troy A.
Thorpe Philip E.
Board Of Regents The University Of Texas System
Peregrine Pharmaceuticals Inc.
R. William Wray & Associates
LandOfFree
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