Fc variants with altered binding to fcrn

Details Fc variants with altered binding to fcrn Fc variants with altered binding to fcrn

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2703997

The present application relates toa variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

La présente invention concerne des variants de région Fc comprenant au moins une modification par rapport à une région Fc humaine de type sauvage, où la modification est choisie dans le groupe constitué de 434S, 252Y/428L, 252Y/434S et 428L/434S, et la numérotation est conforme à l'index UE.

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