Fermentation analogs of virginiamycin m1

Details Fermentation analogs of virginiamycin m1 Fermentation analogs of virginiamycin m1

C - Chemistry, Metallurgy

12

P

195/101, 167/180

C12P 17/18 (2006.01) C12P 1/06 (2006.01) C12P 17/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1279278

TITLE OF THE INVENTION FERMENTATION ANALOGS OF VIRGINIAMYCIN M1 ABSTRACT OF THE DISCLOSURE Virginiamycin M1 having the Formula: Image and virginiamycin M1 analogs having the Formulae I-IV: Image (I) Image (II) Image (III) Image (IV) Virginiamycin M1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin Ml and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.

551943

Affiliated with

Also associated with

Rating

Fermentation analogs of virginiamycin m1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fermentation analogs of virginiamycin m1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fermentation analogs of virginiamycin m1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1186342