Fermentation of 7-(1,2,6,7,8,8a(r)-hexa-hydro-2(s),...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/14 (2006.01) C12P 7/42 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2070148

Novel strains of Aspergillus terreus have been discovered which provide fermentation production of at least 5.2 g/L of 7-[1,2,6,7,8,8a(R)-hexahydro-2(S), 6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R), 5(R)-dihydroxyheptanoic acid (triol acid; I), but with production of not more than 0.85 g/L of (triol acid)-related side products and specifically less than 0.10 mg/liter of lovastatin. The predominant fermentation product triol acid, may be converted in a straightforward manner to its lactone form, in which it is an inhibitor of HMG-CoA reductase and thus useful as an antihyper-cholesterolemic agent, and in which it may also serve as an intermediate for preparation of other HMG-CoA reductase inhibitors.

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