A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01)
Patent
CA 2384696
Disclosed herein are methods for treating tumors which express or over-express the tumor associated antigen (TAA) fibroblast growth factor 5 (FGF-5), including renal cell carcinoma (RCC) and carcinoma of the prostate and breast. Methods include modulating an immune response, such as increasing an immune response, or modulating FGF-5 expression or activity. The disclosure also includes methods of determining if a subject has an enhanced susceptibility to a disease associated with abnormal FGF-5 expression.
L'invention concerne des procédés pour traiter les tumeurs exprimant ou surexprimant le facteur de croissance des fibroblastes (FGF-5) de l'antigène associé aux tumeurs (TAA), y compris au carcinome des cellules rénales (RCC) et au carcinome de la prostate et du sein. Les procédés consistent à moduler une réponse immunitaire, par exemple, à augmenter une réponse immunitaire, ou à moduler l'expression ou l'activité de FGF-5. L'invention porte aussi sur des procédés pour déterminer une éventuelle susceptibilité d'un sujet vis-à-vis d'une maladie associée à l'expression anormale des FGF-5.
Hanada Ken-Ichi
Yang James C.
Smart & Biggar
The Government Of The United States Of America
LandOfFree
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