C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/10 (2006.01) A01N 1/02 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 233/54 (2006.01) C07D 233/68 (2006.01) C07D 233/70 (2006.01) C07D 233/84 (2006.01) C07D 233/90 (2006.01) C07D 401/00 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)
Patent
CA 2227112
Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Compounds of the formula I (see fig. I) in which the symbols have the meanings indicated in the claims, have outstandingantiarrhythmic properties and exhibit a cardioprotective component. They can preventively inhibit or greatly decrease the pathophysiological processes in theformation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias. Moreover, they have a potent inhibitory action on the proliferation of cells.
Hétérocycles à cinq chaînons substitués par biphénylsulfonyle; mode de préparation; utilisation comme médicament ou diagnostic; et médicaments en comprenant. Les composés de la formule I (voir fig. I), dont la signification des symboles est donnée dans la revendication du brevet, ont des propriétés antiarythmisantes exceptionnelles et possèdent une composante cardioprotectrice. Ils peuvent inhiber à titre préventif ou ralentir considérablement les processus pathophysiologiques qui entrent en jeu dans les atteintes dues à l'ischémie, et notamment dans le déclenchement des arythmies cardiaques d'origine ischémique. Ils ont en outre une puissante action inhibitrice sur la prolifération cellulaire.
Faber Sabine
Jansen Hans-Willi
Kleemann Heinz-Werner
Lang Hans Jochen
Schwark Jan-Robert
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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