Flow cell and method of separating carrier-free...

G - Physics – 21 – G

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G21G 4/08 (2006.01) A61K 51/04 (2006.01) A61M 5/178 (2006.01) A61M 5/20 (2006.01)

Patent

CA 2477060

The invention relates to a flow cell, a method for separating carrier-free radionuclides from a liquid or liquefiable target material, and the radiochemical reaction thereof. According to prior art, flow cells are known which require reaction volumes corresponding to the volume of the target material in order to carry out the desired reactions. The inventive flow cell (1) and method enable the reaction volume, and thus the quantity of starting material, to be reduced by a multiple by reducing the cylinder volume (= reaction volume). As the radioactively marked product is present in very small quantities (picomole to nanomole), the HPL-chromatographic separation of the non-reacted starting material is significantly improved. The economic efficiency of the method is increased due to the fact that small quantities of starting material can be used.

La présente invention concerne une cellule d'écoulement et un procédé de séparation de radionucléides dépourvus de porteurs d'une matière cible liquide ou liquéfiable, et leur conversion radiochimique. Les cellules d'écoulement de l'état de la technique requièrent pour la mise en oeuvre des réactions souhaitées des volumes réactionnels qui correspondent au volume de la matière cible. La cellule d'écoulement (1) et le procédé de l'invention permettent désormais, grâce à la réduction du volume de cylindre (= volume réactionnel), au volume réactionnel et donc à la quantité d'éduit, d'être réduits d'un certain multiple. Comme le produit marqué par radioactivité est présent en des quantités très limitées (pico- à nanomole), la séparation par chromatographie HPL de l'éduit non converti est significativement améliorée. Comme de faibles quantités d'éduit peuvent être employées, le rendement du procédé est amélioré.

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