Fluorinated pyridine n-oxide thrombin modulators and process...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/89 (2006.01) A61K 31/444 (2006.01) A61P 7/02 (2006.01) C07D 215/60 (2006.01) C07D 239/24 (2006.01) C07D 241/10 (2006.01)

Patent

CA 2605480

The present invention describes compounds of Formula I or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal. The present invention also relates to a novel method of N-oxidation of nitrogen containing heteroaryls.

L'invention concerne des composés représentés par la formule I ou un sel pharmaceutiquement acceptable de ceux-ci, destinés à prévenir ou à traiter chez un mammifère des maladies ou des états pathologiques liés à l'activité de la thrombine. L'invention concerne aussi un nouveau procédé de N-oxydation d'hétéroaryles azotés.

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