C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/56 (2006.01) C07K 1/36 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2362826
A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nano- filtration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/metal salt to form a solubilized echinocandin nucleus salt having the desired anion, and subsequent cooling of the mixture to crystallize the salt.
L'invention concerne un procédé permettant de former un sel cristallin de noyau d'Echinocandine, à partir de son bouillon mixte et/ou de flux de traitement partiellement purifiés. Ce procédé consiste à effectuer une nano-filtration afin de former un concentrat, à ajouter un agent de dérivatisation aldéhyde qui interagit avec une impureté aldéhyde, à ajouter un sel d'acide/métallique afin de former un sel de noyau d'échinocandine dissous possédant l'anion désiré, puis à refroidir le mélange afin de cristalliser ledit sel.
Dalder Brian Weston
Dotlich Michael Anthony
Kallman Neil John
Larsen Samuel Dean
Snorek Sharon Van Den Berghe
Borden Ladner Gervais Llp
Eli Lilly And Company
LandOfFree
Formation and anion-exchange of crystalline echinocandin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Formation and anion-exchange of crystalline echinocandin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Formation and anion-exchange of crystalline echinocandin... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1949141