A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2354266
The invention relates to a formulation containing a compound which essentially prevents the enterohepatic circulation of nucleotide synthesis inhibitors or antagonizes the effect of the nucleotide synthesis inhibitors in a delayed manner; and a nucleotide synthesis inhibitor such as brequinar, mycophenolate mofetile, 2-morpholinoethly-(E)-6-(1,3-dihydro-4-hydroxy-6- methoxy-7-methyl-3- oxoisobenzofuran-5-yl-4-methyl-4-hexenoate, methotrexate, mizoribine and compounds of formula (I) or (II). Said formulation is suitable for treating immunological diseases or cancer or for transplantations.
Formulation comprenant un composé qui inhibe sensiblement la circulation entéro-hépatique des inhibiteurs de la synthèse des nucléotides ou qui a une action antagoniste retard par rapport auxdits inhibiteurs; et un inhibiteur de la synthèse des nucléotides tel que le bréquinar, le mycophénolate mofetil, le 2-morpholino-éthyl-(E)-6-(1,3-dihydro-4-hydroxy-6-méthoxy-7-méthyl-3-oxoisobenzofuran-5-yl-4-méthyl-4-hexénoate, le méthotrexate, la mizoribine et des composés de formule (I) ou (II). Cette formulation peut être utilisée dans le traitement des troubles immunologiques et du cancer, ainsi que dans les greffes.
Haase Burkhard
Lindner Jurgen
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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