Frizzled-binding agents and uses thereof

Details Frizzled-binding agents and uses thereof Frizzled-binding agents and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2738485

Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Cette invention concerne de nouveaux agents anticancéreux comprenant, sans caractère limitatif, des anticorps, qui se lient aux récepteurs Frizzled humains. De nouveaux épitopes au sein des récepteurs Frizzled humains qui peuvent servir de cibles aux agents anticancéreux sont également identifiés. Des procédés d'utilisation desdits agents ou anticorps, tels que des procédés d'utilisation desdits agents ou anticorps pour inhiber la signalisation Wnt et/ou inhiber la croissance tumorale sont, en outre, décrits.

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