Fully human monoclonal antibodies to il-13

Details Fully human monoclonal antibodies to il-13 Fully human monoclonal antibodies to il-13

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 11/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2587903

Antibodies directed to IL-13 and uses of such antibodies. For example human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.

L'invention concerne des anticorps dirigés contre l'IL-13 et des utilisations desdits anticorps. L'invention porte, par exemple, sur des anticorps monoclonaux humains dirigés contre l'IL-13. L'invention se rapporte aussi à des séquences de polynucléotides isolés codant pour des molécules d'immunoglobuline à chaîne lourde et à chaîne légère et sur des séquences d'acides aminés comprenant lesdites molécules, en particulier des séquences correspondant à des séquences de chaînes lourdes et légères contiguës couvrant les régions charpentes ("framework regions" ou FR) et/ou les régions déterminantes de complémentarité ("complementarity determining regions" ou CDR). L'invention concerne en outre des procédés d'utilisation des anticorps précités dans le traitement de patients. L'invention porte également sur des biomarqueurs dépendant d'IL-13 et sur des procédés permettant leur identification et leur utilisation.

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